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Plant alkaloid that arrests the cell cycle in G2/M phase by blocking mitotic spindle formation. Inhibits normal microtubule asembly and causes aberant tubulin polymerization. Blocks binding of tubulin to microtubule proteins. Induces apoptosis. Triggers Raf-1 activation, phosphorylation of Bcl-2 family proteins and induction of p53 expression. Cancer chemotherapeutic agent. Alternative name: Vincaleukoblastine . sulfate. Purity: ≥98% (HPLC). Appearance: White to light yellow crystalline powder. Solubility: Soluble in DMSO, methanol or water (25mg/ml). Long Term Storage: -20°C.
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Venlafaxine (CAS 99300-78-4) is a small molecule characterized as a dual inhibitor of serotonin and noradrenaline reuptake transporters It exhibits approximately 30-fold greater affinity for the serotonin transporter (SERT K sub i /sub 82 nM) relative to the noradrenaline transporter (NET K sub i /sub 2480 nM) In preclinical models venlafaxine has been shown to enhance swimming and climbing behaviors in the rat forced-swim test indicative of antidepressant-like activity This compound is utilized in research settings to investigate the pharmacological modulation of monoaminergic neurotransmission and the neurobiological mechanisms underlying antidepressant responses
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Nordoxepin hydrochloride is the major metabolite of the tricyclic antidepressant doxepin. Supplied as a high-purity chemical standard for laboratory research and analytical applications, this compound is intended for research use only.
Major metabolite of doxepin, useful in metabolism and analytical studies.
Purity 99.94% suitable for analytical applications.
Solid, white to off-white; easy to handle and store.
Molecular formula C18H20ClNO and molecular weight 301.81 g/mol.
Storage: sealed, away from moisture; in solvent -80°C (up to 6 months) or -20°C (up to 1 month).
Available in multiple package sizes and solution forms for experimental flexibility.
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